Coenzyme Q10, also known by its acronym CoQ10O2, is a fat-soluble nutrient found in nearly all living organisms’ mitochondria and found predominantly in fat cells. It exists in three oxidation states (see Figure 1): fully reduced (ubiquinol form); radical semiquinone intermediate; and fully oxidized form. CoQ10 is widely known for preventing damage to proteins, lipids, and DNA by acting as an antioxidant and protecting them against free radical attack.

CoQ10 can increase ATP concentration in mitochondrial membranes through electron transfer and decreased formation of superoxides, and can protect the heart during oxygen-deprivation conditions such as myocardial infarction or surgery by protecting mitochondrial function, inhibiting oxidative damage and apoptosis, and regulating autophagy (35, 36). (35, 36)

Concentrations levels of both reduced and oxidized forms of CoQ10 decline with age and are linked to changes in energy metabolism. Supplementing with highly bioavailable CoQ10 used by respiration has been reported to slow this decline and increase life span in animals (37-38). Unfortunately, no human studies using CoQ10 supplementation have been published yet in peer-reviewed scientific literature.

Anecdotal reports indicate that high-dose supplemented coenzyme Q10 could potentially prolong survival among people living with certain cancers; however, further research needs to be completed in this field. As CoQ10 may interfere with warfarin (Jantoven), so it is important to inform your physician if you plan to use this blood-thinning agent or are already taking it. Our advanced clinical trial search allows users to locate NCI-supported cancer trials currently enrolling participants.